Lexapro and Wellbutrin are very good choices for anxiety, primarily when it has to do with depression interfering with your day-to-day function. Lexapro (escitalopram) targets anxiety by increasing serotonin levels, helping us adjust to mood changes and reduce anxious feelings. Wellbutrin (bupropion) can increase norepinephrine and dopamine to bring more drive and focus.
Most people will use Lexapro to combat anxious thoughts and bupropion to increase motivation and focus. In some cases, doctors will put a patient on both to improve focus and elevate mood with minimal sedation. They help with emotional breakdowns and boost concentration, performance, and overall mental state. Most will start to notice pretty soon that their focus and mood increase over time. This can combat emotional breakdowns. Patients are seen periodically to monitor effectiveness and side effects and to try to reduce the dose.
What Is Wellbutrin?
Doctors use Wellbutrin to treat patients with depression and to help those who want to quit smoking. When the medication is taken, it works by affecting both dopamine and norepinephrine within the brain. These neurotransmitters affect moods and feelings. Many patients on Wellbutrin report feeling better and more energetic after a few weeks. Other patients report an increase in weight or a decrease in sex drive with this different class of antidepressant.
Some doctors prescribe Wellbutrin to those who may be inattentive or have seasonal affective disorder. Doctors administer Wellbutrin orally as tablets, prescribing it once or twice daily. As with any other drug, if the person is allergic,c it can affect one’s sleeping pattern, also the person might have a dry mouth or a feeling of being weak or lightheaded. As always, follow the prescribing doctor’s instructions and provide information about your medical conditions and medications. With MAVA Behavioral Health, medication management services focuses on careful evaluation, ongoing monitoring, and tailored treatment plans to meet individual needs.
What Is Lexapro?
Some people may use Lexapro for anxiety and depression. It does this by increasing the amount of brain chemical serotonin, which can impact sleep, mood, and emotions. Stable serotonin levels can sometimes help people feel comfortable in general. In many patients, we can observe effects within several weeks. Patients must follow instructions for taking the medication.
Lexapro may be taken as a liquid or as a pill one time per day. Some common side effects associated with taking Lexapro include drowsiness, nausea, and sleep issues. Many of the minor side effects are temporary and will subside within several days. It is not safe to suddenly stop taking Lexapro without a doctor’s guidance, as the side effects will be similar to those seen upon starting the medication. Follow your doctor’s guidance and report any side effects or concerns.
Functioning of Wellbutrin and Lexapro
Wellbutrin (Bupropion)
- Norepinephrine-dopamine reuptake Inhibitor (NDRI)
- Wellbutrin causes an increase in the levels of norepinephrine and dopamine in the brain, and thus the amount of the neurotransmitters is reabsorbed more slowly, resulting in an increase in mood and concentration.
- Healthcare providers often prescribe it for individuals with major depressive disorder and seasonal affective disorder.
- As a relative of the other antidepressants, this medication is known for creating a more energized feel and is less likely to cause weight and sexual side effects.
Lexapro (Escitalopram)
- This class is Selective Serotonin Reuptake Inhibitors, or SSRIs.
- Lexapro works by preventing certain receptors in the brain from working, and this in turn increases serotonin levels in the brain.
- Serotonin influences the way we feel, our sleep patterns, and our overall anxiety levels. SSRIs are usually used to treat depression and GAD but may also be effective in panic disorder and social anxiety.
- This is relaxing on the body and is often used to help people feeling anxious symptoms.
- Some people suffer side effects such as sex problems or an increase in weight.
Lexapro and Wellbutrin: Which Is Better?
Different medications such as Lexapro and Wellbutrin are available to treat depression. Researchers believe Lexapro boosts serotonin in the brain, making you feel happier, increase well-being, and reduce anxiety. So, you may get a lot better taking certain antidepressants, and the symptoms of the disorder may decrease and sometimes go away but not always; there can also be problems that may go wrong. For example:
Wellbutrin has the same effect of boosting different neurotransmitters such as dopamine and norepinephrine. So, the advantages that can occur from this treatment are increased energy levels and alertness. It may be beneficial if you have felt particularly tired, unfocused or lacking motivation and have experienced sexual side effects when taking different antidepressants. This would be worth talking to your doctor about to get treatment for it. Access MAVA Behavioral Health for telehealth services easily to obtain expert, confidential service from home with flexibility, continuity, and excellent follow-up.
Benefits of Lexapro and Wellbutrin
1. Alleviates Anxiety
Lexapro can be useful for easing the level of your anxiety. The Lexapro will quiet your brain, calm panicky impulses, and allow you to control your all-consuming and sometimes overwhelming anxiety about your endless fears. Lexapro greatly reduces anxiety and symptoms in patients with generalized anxiety disorder, panic attacks, and social anxiety. With calm and steady feelings, your life may become considerably easier.
2. Relieves Depression
Lexapro effectively increases serotonin in your brain to treat depression. Lexapro increases happiness, dampens sadness, and stabilizes emotions. In turn, you should feel increasingly less angry and a generally more optimistic view of the future. You will feel decreased amounts of hopeless and tearful feelings, along with emotions that have been numbed.
3. Increased power and desire to work
Upon taking this medicine, you will feel more alert and full of vigor. Your dosage will increase dopamine and norepinephrine levels, while on the medication, which will cause you to feel more determined and to want to complete tasks that need to be done. Your capacity to draw on your strength to accomplish other things will increase and will later be useful to patients with lower working power due to depression.
4. Increases the ability to concentrate
It also helps to focus and persist on tasks. At times, this drug is prescribed for those with similar symptoms to ADHD, though primarily for adults. It’s primarily targeted to sharpen focus if your mind is often cloudy, you can’t seem to remember things, or you are easily distracted.
Why Do Doctors Prescribe Lexapro and Wellbutrin Together?
Many doctors would recommend using both Wellbutrin and Lexapro. In addition to the doctors’ recommendations you should use these medications in combination with one another to help with the problem. Lexapro effects serotonin levels and the serotonin could potentially increase your mood and reduce your anxiety, but this can be one of the reasons that Lexapro may lower your energy and sex drive. The effects on the other neurotransmitters from Wellbutrin, norepinephrine and dopamine. It may increase your energy, ability to be motivated and your concentration levels positively. Wellbutrin may reduce the impact of low energy and low sex drive resulting from an unfavorable side effect from Lexapro.
The National Library of Medicine, explains that Wellbutrin helps to modify dopamine and norepinephrine in the brain, which could lead to better energy, motivation, and focus. This may be especially beneficial in a person that already has energy and concentration issues. One aspect as to why a person may be on this combination of medications is because if a person has both depression and anxiety, the drugs may work sufficiently enough together, or if one does not completely fix depression/anxiety, then the other can work. A contributing aspect is that they allow for more then one chemical action in the brain to be changed. While it does no harm to be on both, always take this with a doctor’s approval because reactions to the medicine vary.
Difference Between Lexapro and Wellbutrin
Lexapro |
Wellbutrin |
| SSRI (Selective Serotonin Reuptake Inhibitor)
It boosts serotonin to help mood and anxiety. |
Boosts dopamine and norepinephrine for focus and energy.
|
| Good for calming and improving emotional balance.
|
Helpful for low energy and motivation.
|
| It can help reduce anxious thoughts and sadness.
|
It may improve motivation and alertness.
|
| It can increase appetite or slow metabolism.
|
Less likely to affect appetite.
|
| It may cause drowsiness or better sleep.
|
It may cause insomnia or restlessness.
|
| Often, the first choice for treating constant worry.
|
It can sometimes make anxiety worse in sensitive people.
|
Lexapro and Wellbutrin Combo Side Effects
Some general effects that are common when on Lexapro with Wellbutrin are written as bullet points:
- This is one that very commonly occurs on Wellbutrin.
- The simultaneous combination of the two often causes sleep problems and/or problems with the quality of your sleep.
- Anxiety can increase when starting Wellbutrin in the first few days.
- The effects can also occur due to adaptation to the simultaneous effects of both drugs.
- Appetite changes when a person is on Lexapro and also when on Wellbutrin.
- Patients often feel they sweat at night more than they do at other times of the day.
- Seizures increase their risk when switching to higher dosages of Wellbutrin.
- It usually comes in conjunction with high doses of Wellbutrin, especially those who are sensitive.
Important Note:
All the details provided in this article aim for informational and educational purposes. Please don’t consider it medical advice or a substitute for a psychiatric evaluation. For professional guidance and treatment, consult with our licensed healthcare professionals at MAVA Behavioral Health.
To sum Up
The mixture of both anxiety and depression in a single patient is something that many physicians will prescribe a combination of Lexapro and Wellbutrin to manage. Anxious feelings are countered when you can balance them with the increase of serotonin and emotional well-being promoted by the Lexapro that will enable the patient to not worry and be calm, while a sense of motivation and energy can be spurred on by Wellbutrin when the depression is helped by boosting the dopamine and norepinephrine when a person with both anxieties and depression is experiencing a deep sense of fatigue.
This combination usually produces an increase in overall mood, concentration, and day-to-day function by making the patient more energetic and more centered while on it daily. Understand that every person will respond to their medicine differently, and it is important that you stay in communication with your physician so that the medication is effective. If you are seeking help creating a medication plan, the MAVA Behavioral Health organization can guide you with a proper assessment and personal action plan to assist you.
FAQs
What is Lexapro prescribed for?
They are used to restore the balance of serotonin in the brain and to relieve the symptoms of anxiety and depression. Wellbutrin is used to treat a multitude of things, but most commonly depression, symptoms of depression as a result of anxiety, or to aid the cessation of smoking. These drugs both treat mood, however, in different ways, and aid in improving your mental state.
Can you take lexapro and Wellbutrin together?
Both Lexapro and Wellbutrin may be prescribed at the same time if one drug does not treat all the symptoms. The combination should not be undertaken without strict medical advice, as they can be risky with both drug interactions and side effects, with an increased possibility of seizures or serotonin syndrome.
What are the side effects of Lexapro and Wellbutrin?
Side effects of Lexapro often include nausea, fatigue, headache, dizziness, and sexual dysfunction. Dry mouth, insomnia, an increased heart rate, increased sweating, and sometimes anxiety may occur from Wellbutrin. Normally, side effects occur as the body adjusts to a new medication.
How quickly do we feel the effects?
With either medication, it generally takes 4-6 weeks for an improvement, and some people notice an improvement sooner. It is essential to stay on the medication as instructed and to consult with your doctor about further issues.
Do these medications lead to withdrawal symptoms?
Symptoms can occur when you stop Lexapro abruptly, such as dizziness, irritability, flu-like symptoms, and so forth. Wellbutrin is less likely to cause withdrawal if you taper off the medication with a doctor.



